Table 1. Clinical characteristics of the study participants
Total cohort uncomplicated malaria (n = 53)Total cohort cerebral malaria (n = 60)P‐valueUsed in assay uncomplicated malaria (n = 35)Used in assay cerebral malaria (n = 27)P‐value
Age, months51 (30–74)42 (24–59)0.0453 (38–89)36 (23–50)0.005
Gender, % female53475148
Axillary temperature, °C38.8 (38.2–39.4)39.0 (38.1–40.0)38.8 (381–39.4)39.0 (37.9–40.0)
Pulse rate, beats/min124 (107–140)157 (140–175)< 0.0001124 (114–146)156 (133–175)0.0001
Systolic blood pressure, mmHg98 (91–102)95 (86–104)a97 (91–99)94 (85–103)b
Respiratory rate, breaths/min30 (25–30)40 (36–52)< 0.000128 (24–30)41 (32–52)< 0.0001
Blood glucose, mmol/l5.7 (5.1–6.4)5.4 (4.4–6.8)5.8 (5.1–6.5)5.0 (4.5–6.7)
Blood lactate, mmol/l2.9 (2.0–3.4)4.5 (2.4–8.8)< 0.00012.9 (1.9–3.5)4.6 (2.3–8.2)0.0006
Haematocrit, %35.0 (30.0–38.0)22.0 (18.0–25.6)< 0.000136.0 (29.5–38.0)20.4 (16.8–25.1)< 0.0001
HRP2, μg/ml7.1 (2.2–9.9)c9.5 (3.1–11.0)d
Parasitaemia, parasites/μl (×104)11.8 (4.2–38.4)29.8 (14.6–59.9)
Platelets/μl (×104)4.9 (2.4–9.6)c4.9 (2.4–9.8)d
  • Shown are the median with the interquartile range in brackets for the total cohort and the cases used in the binding assays. For each variable, statistical differences between UM and CM cases were determined by Mann–Whitney U‐test (continuous variables) or Fisher's exact test (categorical variables), and P‐values < 0.05 are indicated. HRP2 = histidine‐rich protein 2. Group size in a = 50, b = 21, c = 55 and d = 24 children.