Table 2. Transcript levels of var gene domains by patient group
TargetPredicted receptorUMCMP‐value
DomainGroupnTunTu
CIDRα1.1B/AEPCR342.6 (1.0–28.9)2224.1 (2.0–114.9)< 0.0001
CIDRα1.8aB/AEPCR301.0 (1.0–24.4)232.9 (1.0–75.0)0.040
CIDRα1.8bB/AEPCR311.0 (1.0–8.5)231.0 (1.0–16.2)
Sum: CIDRα1.DC8 B/AEPCR314.6 (1.0–37.1)2233.9 (4.7–166.1)< 0.0001
CIDRα1.4AEPCR341.0 (1.0–5.6)243.0 (1.0–29.7)0.002
CIDRα1.5aAEPCR331.0 (1.0–2.1)231.0 (1.0–30.1)0.004
CIDRα1.5bAEPCR341.0 (1.0–15.5)234.6 (1.0–105.0)
CIDRα1.6aAEPCR311.0 (1.0–1.0)231.0 (1.0–20.2)0.005
CIDRα1.6bAEPCR311.0 (1.0–8.5)231.0 (1.0–8.4)
CIDRα1.7AEPCR341.2 (1.0–10.4)238.5 (1.0–35.4)0.0007
Sum: CIDRα1.A AEPCR304.3 (1.0–35.6)2343.6 (6.9–136.7)< 0.0001
Sum:CIDRα1_all A & B/AEPCR309.3 (1.0–81.6)23104.6 (14.2–218.2)< 0.0001
DBLζ2a311.0 (1.0–3.1)231.3 (1.0–6.6)0.043
DBLζ2b251.0 (1.0–2.8)191.0 (1.0–6.6)
DBLζ2c251.0 (1.0–3.9)191.0 (1.0–32.4)0.048
DBLζ3311.5 (1.0–9.4)233.2 (1.1–24.0)0.009
DBLζ4314.3 (1.0–75.2)236.3 (1.1–55.0)
DBLζ5311.4 (1.0–17.9)236.6 (1.0–129.9)0.011
DBLζ6251.5 (1.0–10.0)183.8 (1.0–27.0)
Sum: DBLζ_all 2521.3 (3.4–95.3)1944.0 (13.9–389.1)0.035
DBLε2251.0 (1.0–1.0)191.0 (1.0–5.4)0.004
DBLε6251.4 (1.0–9.8)195.7 (1.0–33.2)
DBLε11251.0 (1.0–15.3)191.3 (1.0–23.7)
DBLε13318.9 (1.0–87.6)2314.2 (1.1–126.8)
DBLε14251.0 (1.0–1.0)191.0 (1.0–2.9)
Sum: DBLε_all 2516.8 (1.06–123.8)1936.1 (4.1–147.8)
DBLβ1/3‐1AICAM‐1331.0 (1.0–7.7)236.6 (1.0–24.1)0.0001
DBLβ1/3‐2A(ICAM‐1)341.3 (1.0–30.8)231.5 (1.0–29.1)
DBLβ5BICAM‐1342.1 (1.0–26.1)234.7 (1.0–31.2)0.021
DC5APECAM‐1321.0 (1.0–19.3)235.3 (1.0–61.9)0.024
CIDRα3.1/3.2B/CCD36341.1 (1.0–7.8)232.0 (1.0–8.0)
CIDRδA332.4 (1.0–25.0)2313.7 (1.4–69.7)0.003
CIDRγ3.1A281.0 (1.0–6.5)191.0 (1.0–1.5)
DBLα1allA3431.1 (3.2–111.3)2390.5 (35.2–257.8)< 0.0001
DBLα2/1.1/1.2/1.4/1.7A3432.3 (6.4–117.7)23134.8 (26.7–428.1)< 0.0001
DBLα1.5/1.6/1.8ANon‐EPCR3416.5 (2.3–66.9)2346.9 (4.9–107.6)0.0006
var2csaECSA254.8 (1.0–44.7)198.7 (1.0–135.3)
var3A251.0 (1.0–5.2)191.0 (1.0–6.8)
CIDRα1.2‐K231.0 (1.0–1.4)181.0 (1.0–1.4)
CIDRα1.2‐K+CIDRα1.3‐K311.0 (1.0–3.1)231.0 (1.0–4.0)
  • The transcript unit (Tu) was calculated for the primer sets and shown are the median, with the 10th and 90th percentiles in brackets. In bold are the specific groups, which are the sum of the Tu values of primers listed above it. For DBLζ_all, only the highest Tu value of either DBLζ4 or DBLζ6 was included. Receptor names in brackets are probable and left blank when unknown. Number of cases in the analysis (n) is specified, and statistical differences between UM and CM cases were determined by Mann–Whitney U‐test and P‐values < 0.05 are indicated.