Table 3. Diagnostic accuracy of CSF biomarkers
GroupsModelT‐tauNgNFLAUC (95% CI)AIC
AD versus CNT‐tau only 1.61 (< 0.001) 80.8 (74.3–86.4)216.3
Ng only 0.85 (< 0.001) 71.4a (64.1–77.9)254.7
NFL only 1.38 (< 0.001) 77.7 (71.4–83.8)228.9
T‐tau & Ng 2.11 (< 0.001) −0.56 (0.074)81.4b (75.2–87.3)215.0
T‐tau & NFL 1.33 (< 0.001) 0.98 (< 0.001) 84.9a,b,c (79.8–89.8)198.1
Ng & NFL 0.61 (0.0016) 1.19 (< 0.001) 80.6b,c,e (74.7–86.2)219.7
T‐tau & Ng & NFL 1.80 (< 0.001) −0.52 (0.11) 0.99 (< 0.001) 85.5a–f (80.6–90.6)197.4
PMCI versus SMCIT‐tau only 0.56 (0.0035) 67.7 (58.6–75.2)219.2
Ng only 0.39 (0.027) 60.4a (50.6–68.8)223.9
NFL only0.32 (0.069)58.9 (48.8–68.0)225.6
T‐tau & Ng 0.60 (0.038) −0.046 (0.86)68.2b (58.4–76.2)221.2
T‐tau & NFL 0.52 (0.0082) 0.20 (0.23)67.5b,c (58.1–76.0)219.7
Ng & NFL 0.38 (0.29) 0.30 (0.076)63.0 (54.2–72.3)222.5
T‐tau & Ng & NFL0.49 (0.10)0.028 (0.92)0.21 (0.23)67.3b,c (59.0–76.5)221.7
  • A separate logistic regression model was fit for each combination of neurodegeneration biomarkers in AD dementia versus CN and in PMCI versus SMCI. The table includes coefficients (log odds) with P‐values, AUC, and AIC. For AUC, the letters a‐f indicate significant differences (P < 0.05, tested by bootstrap) versus other models: T‐tau (a), Ng (b), NFL (c), T‐tau & Ng (d), T‐tau & NFL (e), Ng & NFL (f). Bold values indicate significant associations. AD, Alzheimer's disease dementia; AIC, Akaike information criterion; AUC; area under the receiver operating characteristic curve; CN, healthy controls; PMCI, progressive mild cognitive impairment; SMCI, stable mild cognitive impairment.