Table 5. Associations between biomarkers, clinical diagnosis and amyloid pathology
ComparisonCSF T‐tauCSF NgCSF NFLDifference T‐tau versus NgDifference T‐tau versus NFLDifference Ng versus NFL
Associations between neurodegeneration biomarkers and Aβ pathology within diagnostic group
CN Aβ versus CN Aβ+ 0.528 (0.0069) 0.332 (0.087)0.102 (0.60)0.197 (0.32) 0.426 (0.031) 0.229 (0.24)
MCI Aβ versus MCI Aβ+ 0.824 (< 0.001) 0.727 (< 0.001) 0.00778 (0.96)0.0970 (0.61) 0.816 (< 0.001) 0.719 (0.00015)
AD Aβ versus AD Aβ+ 0.789 (0.040) 0.618 (0.11)−0.632 (0.098)0.171 (0.67) 1.420 (0.00057) 1.249 (0.0024)
Associations between neurodegeneration biomarkers and combinations of clinical diagnosis and Aβ pathology
CN Aβ versus CN Aβ+ 0.528 (0.0069) 0.332 (0.087)0.102 (0.60)0.197 (0.32) 0.426 (0.031) 0.229 (0.24)
CN Aβ versus MCI Aβ+ 0.916 (< 0.001) 0.816 (< 0.001) 0.798 (< 0.001) 0.100 (0.52)0.119 (0.45)0.0185 (0.91)
CN Aβ versus AD Aβ+ 1.172 (< 0.001) 0.860 (< 0.001) 0.973 (< 0.001) 0.312 (0.045) 0.199 (0.20)−0.113 (0.47)
CN Aβ versus MCI Aβ0.119 (0.51)0.120 (0.51) 0.633 (0.00067) −0.00141 (0.99) −0.514 (0.014) −0.513 (0.015)
CN Aβ versus AD Aβ0.494 (0.18)0.0564 (0.88) 1.40 (0.00028) 0.438 (0.24) −0.909 (0.016) −1.35 (0.00040)
  • Results for comparisons between different combinations of clinical diagnosis and Aβ pathology (CN Aβ, n = 69; CN Aβ+, n = 40; MCI Aβ, n = 50; MCI Aβ+, n = 137; AD Aβ, n = 8; AD Aβ+, n = 85) from linear mixed‐effects models testing effects of Aβ within diagnostic groups (top 3 rows), and differences between Aβ CN and other combinations of Aβ and diagnosis (bottom 5 rows). The data correspond to Fig 2. Results are β‐coefficient (P‐value). For example, in the top row (“CN Aβ versus CN Aβ+”), the effect of T‐tau indicates that CN Aβ+ was significantly associated with 0.528 standard deviations higher levels of T‐tau. The columns marked “difference” test whether the comparison differed between two biomarkers. For example, in the top row (“CN Aβ versus CN Aβ+”), the difference for T‐tau versus NFL indicates that CN Aβ+ was significantly more associated with T‐tau than with NFL. Bold values indicate significant associations. CN, healthy controls; MCI, mild cognitive impairment; AD, Alzheimer's disease dementia.