Table 1. The different predictions of the effects of the three human variants on WBP2 protein by six mutation predictors
p.Ala224Valp.Ala160Thrp.Met163Leu
FathmmToleratedToleratedTolerated
Mutation Assessor Medium impact Low impactLow impact
Mutation Taster Disease causing Disease causing Disease causing
SIFT (manual) Affect protein function ToleratedTolerated
SIFT (automated)ToleratedToleratedTolerated
SIFT (ensembl) Deleterious ToleratedTolerated
PolyPhen2 Possibly damaging BenignBenign
PhD‐SNPNeutralNeutralNeutral
  • The text in the table has been bolded to clearly distinguish predictions that the mutation would be deleterious (bold) from predictions that it would be tolerated (normal text).