Table 4. Change of P‐values upon exclusion of each SNP from the original 8‐SNP accumulation model – internal control
PAUSSBlunted affectPoor rapportSocial withdrawalDifficulties in abstract thinkingSpeech productionStereotyped thinkingMannerismPreoccupation
8‐SNP model (1.5–2.5 versus 5.5–6.5 proautistic genotypes)
(N = 69–73 versus N = 57–68)a
=   0.0002 =   0.020 =   0.002 =   0.0002 = 0.146 =   0.003 = 0.278 =   0.003 =   0.001
SNP taken out of the 8‐SNP accumulation modela
rs25699 (FMR1)
(N = 64 versus N = 11)b
= 0.203= 0.490= 0.766= 0.310= 0.424= 0.114= 0.039c= 0.089= 0.611
rs6763069 (FXR1)
(N = 48 versus N = 24–26)
= 0.195= 0.465= 0.135= 0.181= 0.455= 0.047= 0.242= 0.249= 0.120
rs2601 (FXR1)
(N = 107 versus N = 10)
= 0.595= 0.594= 0.709= 0.358= 0.899= 0.131= 0.239= 0.520= 0.955
rs34416693 (FXR2)
(N = 106 versus N = 18)
= 0.800= 0.766= 0.385= 0.376= 0.625= 0.032= 0.403= 0.325= 0.750
rs62059833 (FXR2)
(N = 110 versus N = 16)
= 0.075= 0.342= 0.291= 0.038= 0.306= 0.007= 0.529= 0.610= 0.528
rs241084 (FMR2)
(N = 95 versus N = 10)
= 0.226= 0.875= 0.986= 0.067= 0.902= 0.529= 0.187c= 0.122= 0.524
rs17318323 (FMR2)
(N = 31 versus N = 49)
= 0.008= 0.039= 0.077= 0.026= 0.230= 0.419= 0.127c= 0.048= 0.005
rs6641482 (FMR2)
(N = 38 versus N = 48)
= 0.118= 0.089= 0.072= 0.119= 0.882= 0.259= 0.955= 0.144= 0.020
  • P‐values ≤ 0.05 in the 8‐SNP accumulation model are set in boldface.

  • a Individuals with 1.5–2.5 proautistic genotypes were compared to individuals with 5.5–6.5 proautistic genotypes by Mann–Whitney U‐test.

  • b N numbers refer to the extreme groups (1.5–2.5 compared to 5.5–6.5 proautistic genotypes).

  • c P‐values improve upon exclusion of the respective SNP only for 3 SNPs regarding stereotyped thinking; for all other SNPs and variables, P‐values worsen upon exclusion of the respective SNP.