Table 1. Effect of liraglutide and RM‐493 co‐treatment on plasma lipids in DIO mice.
Plasma lipidsVehicleLiraglutideRM‐493Liraglutide and RM‐493
Cholesterol (mg/dl)220.0 ± 19.2159.9 ± 9.8*183.0 ± 9.3141.2 ± 14.4**
Triglycerides (mg/dl)79.5 ± 9.356.8 ± 5.189.8 ± 8.569.7 ± 3.1
NEFA (mg/dl)26.1 ± 2.525.7 ± 1.927.0 ± 1.923.3 ± 0.9
  • Plasma lipid parameters in DIO mice maintained on a HFD and treated for 7 days with vehicle, liraglutide (10 nmol/kg), RM‐493 (3.6 μmol/kg), or liraglutide (10 nmol/kg) and RM‐493 (3.6 μmol/kg). Compounds were administered by daily subcutaneous injections. Data represent means ± SEM; = 8; *P < 0.05, **P < 0.01 versus vehicle.