Table 1. Plasma and urine electrolyte levels
Normal Na+‐diet plasma electrolytesSPAK+/+ (mmol/L)SPAK243A/243A (mmol/L)
Na+146.90 ± 0.82 (n = 25)146.30 ± 0.80 (n = 24)
K+5.52 ± 0.13 (n = 22)5.33 ± 0.18 (n = 20)
Cl110.70 ± 0.60 (n = 25)109.10 ± 0.70 (n = 23)
Ca2+2.38 ± 0.01 (n = 25)2.40 ± 0.01 (n = 23)
Mg2+1.12 ± 0.04 (n = 25)1.01 ± 0.02 (n = 23)*
PO43−2.12 ± 0.05 (n = 25)2.05 ± 0.09 (n = 23)
Low Na+‐diet plasma electrolytesSPAK+/+ (mmol/L)SPAK243A/243A (mmol/L)
Na+149.78 ± 1.71 (n = 9)151.45 ± 0.45 (n = 11)
K+3.49 ± 0.13 (n = 9)3.06 ± 0.09 (n = 11)*
Cl109.11 ± 1.49 (n = 9)108.81 ± 0.34 (n = 11)
Ca2+N/DN/D
Mg2+0.77 ± 0.03 (n = 9)0.78 ± 0.02 (n = 12)
PO43−1.92 ± 0.14 (n = 9)2.38 ± 0.11 (n = 12)*
Normal Na+‐diet urine electrolytesSPAK+/+SPAK243A/243A
(ratio of electrolytes/creatinine)
Na+14.33 ± 2.11 (n = 7)15.09 ± 2.45 (n = 6)
K+47.96 ± 4.88 (n = 7)55.03 ± 5.23 (n = 6)
Cl27.31 ± 4.11 (n = 7)32.20 ± 2.57 (n = 6)
Ca2+1.37 ± 0.15 (n = 9)0.95 ± 0.07 (n = 9)*
Mg2+10.40 ± 0.76 (n = 9)10.68 ± 0.61 (n = 8)
PO43−11.24 ± 2.35 (n = 8)17.11 ± 1.42 (n = 8)
Low Na+‐diet urine electrolytesSPAK+/+SPAK243A/243A
(ratio of electrolytes/creatinine)
Na+2.33 ± 0.62 (n = 6)2.19 ± 0.58 (n = 6)
K+43.64 ± 3.11 (n = 6)43.64 ± 2.96 (n = 6)
Cl5.88 ± 0.44 (n = 6)7.19 ± 1.30 (n = 6)
Ca2+0.80 ± 0.16 (n = 8)0.80 ± 0.12 (n = 10)
Mg2+5.49 ± 0.48 (n = 9)5.77 ± 0.39 (n = 10)
PO43−9.44 ± 2.00 (n = 8)8.41 ± 1.52 (n = 10)
  • The indicated mice were fed a normal Na+‐diet (0.3%) or subjected to a restricted Na+‐diet (0.03%) for 2 weeks. Plasma electrolytes are in mmol/L. Urinary electrolytes are expressed as a ratio of electrolyte concentration to creatinine. Bold type/* indicates p < 0.05 versus SPAK+/+. N/D indicates not determined due to insufficient sample.