Cover: “ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth” by Nicola Rath, Michael F Olson and colleagues. The image shows invasive pancreatic tumor cells (blue, DAPI-stained nuclei) preceded by cleaved collagen fibers (red) in a three-dimensional collagen matrix. ROCK activation in the cells increased the production and release of matrix metalloproteinases that induced collagen cleavage. The remodeling of the extracellular matrix allowed cell invasion and proliferation, which was associated with pancreatic cancer progression. Scientific image by Nicola Rath, Cancer Research UK Beatson Institute, Glasgow, UK.