Table of Contents

Research Articles

• Open Access

  Dual inhibition of AKT‐mTOR and AR signaling by targeting HDAC3 in PTEN‐ or SPOP‐mutated prostate cancer

  

  Yuqian Yan, Jian An, Yinhui Yang, Di Wu, Yang Bai, William Cao, Linlin Ma, Junhui Chen, Zhendong Yu, Yundong He, Xin Jin, Yunqian Pan, Tao Ma, Shangqian Wang, Xiaonan Hou, Saravut John Weroha, R Jeffrey Karnes, Jun Zhang, Jennifer J Westendorf, Liguo Wang, Yu Chen, Wanhai Xu, Runzhi Zhu, Dejie Wang, Haojie Huang

  Published online 09.03.2018

  • Cancer
  • Pharmacology & Drug Discovery
• Open Access

  Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1

  

  Rachana Patel, Janis Fleming, Ernest Mui, Carolyn Loveridge, Peter Repiscak, Arnaud Blomme, Victoria Harle, Mark Salji, Imran Ahmad, Katy Teo, Freddie C Hamdy, Ann Hedley, Niels van den Broek, Gillian Mackay, Joanne Edwards, Owen J Sansom, Hing Y Leung

  Published online 14.03.2018

  • Cancer
  • Pharmacology & Drug Discovery
• Open Access

  Inhibition of DDR1‐BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer

  

  Maya Jeitany, Cédric Leroy, Priscillia Tosti, Marie Lafitte, Jordy Le Guet, Valérie Simon, Debora Bonenfant, Bruno Robert, Fanny Grillet, Caroline Mollevi, Safia El Messaoudi, Amaëlle Otandault, Lucile Canterel‐Thouennon, Muriel Busson, Alain R Thierry, Pierre Martineau, Julie Pannequin, Serge Roche, Audrey Sirvent

  Published online 09.02.2018

  • Cancer
  • Digestive System
  • Pharmacology & Drug Discovery
• Open Access

  An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers

  

  Mélanie Mahe, Florent Dufour, Hélène Neyret‐Kahn, Aura Moreno‐Vega, Claire Beraud, Mingjun Shi, Imene Hamaidi, Virginia Sanchez‐Quiles, Clementine Krucker, Marion Dorland‐Galliot, Elodie Chapeaublanc, Remy Nicolle, Hervé Lang, Celio Pouponnot, Thierry Massfelder, François Radvanyi, Isabelle Bernard‐Pierrot

  Published online 20.02.2018

  • Cancer
  • Urogenital System
• Open Access

  Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

  

  Yi Huang, Hua Jiang, Yun Chen, Xiaqiong Wang, Yanqing Yang, Jinhui Tao, Xianming Deng, Gaolin Liang, Huafeng Zhang, Wei Jiang, Rongbin Zhou

  Published online 12.03.2018

  • Immunology
  • Pharmacology & Drug Discovery
• Open Access

  Role of NKp46⁺ natural killer cells in house dust mite‐driven asthma

  

  Eline Haspeslagh, Mary J van Helden, Kim Deswarte, Sofie De Prijck, Justine van Moorleghem, Louis Boon, Hamida Hammad, Eric Vivier, Bart N Lambrecht

  Published online 14.02.2018

  • Immunology
  • Respiratory System
• Open Access

  Counteracting the effects of TNF receptor‐1 has therapeutic potential in Alzheimer's disease

  

  Sophie Steeland, Nina Gorlé, Charysse Vandendriessche, Sriram Balusu, Marjana Brkic, Caroline Van Cauwenberghe, Griet Van Imschoot, Elien Van Wonterghem, Riet De Rycke, Anneke Kremer, Saskia Lippens, Edward Stopa, Conrad E Johanson, Claude Libert, Roosmarijn E Vandenbroucke

  Published online 22.02.2018

  • Immunology
  • Neuroscience
  • Pharmacology & Drug Discovery
• Open Access

  An allosteric inhibitor of Mycobacterium tuberculosis ArgJ: Implications to a novel combinatorial therapy

  

  Archita Mishra, Ashalatha S Mamidi, Raju S Rajmani, Ananya Ray, Rajanya Roy, Avadhesha Surolia

  Published online 26.02.2018

  • Microbiology, Virology & Host Pathogen Interaction
  • Pharmacology & Drug Discovery
• Open Access

  Human ALPI deficiency causes inflammatory bowel disease and highlights a key mechanism of gut homeostasis

  

  Marianna Parlato, Fabienne Charbit‐Henrion, Jie Pan, Claudio Romano, Rémi Duclaux‐Loras, Marie‐Helene Le Du, Neil Warner, Paola Francalanci, Julie Bruneau, Marc Bras, Mohammed Zarhrate, Bernadette Bègue, Nicolas Guegan, Sabine Rakotobe, Nathalie Kapel, Paola De Angelis, Anne M Griffiths, Karoline Fiedler, Eileen Crowley, Frank Ruemmele, Aleixo M Muise, Nadine Cerf‐Bensussan

  Published online 22.03.2018

  • Digestive System
  • Genetics, Gene Therapy & Genetic Disease
  • Metabolism