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CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

Marc Suárez‐Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas‐Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, the Dominantly Inherited Alzheimer Network, the Alzheimer's Disease Neuroimaging Initiative
DOI 10.15252/emmm.201809712 | Published online 27.11.2018
EMBO Molecular Medicine (2018) 10, e9712

Author Affiliations

  1. Marc Suárez‐Calvet (msuarez{at}barcelonabeta.org)*,1,2,21,
  2. Anja Capell1,
  3. Miguel Ángel Araque Caballero3,
  4. Estrella Morenas‐Rodríguez1,4,
  5. Katrin Fellerer1,
  6. Nicolai Franzmeier3,
  7. Gernot Kleinberger1,5,
  8. Erden Eren1,6,7,
  9. Yuetiva Deming8,
  10. Laura Piccio9,10,
  11. Celeste M Karch8,10,11,
  12. Carlos Cruchaga8,10,11,
  13. Katrina Paumier9,10,11,
  14. Randall J Bateman9,10,11,
  15. Anne M Fagan9,10,11,
  16. John C Morris9,10,11,
  17. Johannes Levin2,12,
  18. Adrian Danek12,
  19. Mathias Jucker13,14,
  20. Colin L Masters15,
  21. Martin N Rossor16,
  22. John M Ringman17,
  23. Leslie M Shaw18,19,
  24. John Q Trojanowski18,19,
  25. Michael Weiner20,
  26. Michael Ewers3,
  27. Christian Haass (christian.haass{at}mail03.med.uni-muenchen.de)*,1,2,5,
  28. the Dominantly Inherited Alzheimer Network†,
  29. the Alzheimer's Disease Neuroimaging Initiative‡
  1. 1Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig‐Maximilians‐Universität München, Munich, Germany
  2. 2German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany
  3. 3Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig‐Maximilians‐Universität München, Munich, Germany
  4. 4Department of Neurology, Institut d'Investigacions Biomèdiques, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain
  5. 5Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
  6. 6Izmir International Biomedicine and Genome Institute Dokuz, Eylul University, Izmir, Turkey
  7. 7Department of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey
  8. 8Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
  9. 9Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
  10. 10Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO, USA
  11. 11Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, MO, USA
  12. 12Department of Neurology, Ludwig‐Maximilians‐Universität München, Munich, Germany
  13. 13German Center for Neurodegenerative Diseases (DZNE) Tübingen, Tübingen, Germany
  14. 14Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
  15. 15The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Vic., Australia
  16. 16Dementia Research Centre, UCL Institute of Neurology, London, UK
  17. 17Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
  18. 18Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  19. 19Center for Neurodegenerative Disease Research, Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  20. 20University of California at San Francisco, San Francisco, CA, USA
  21. 21Present Address: Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Catalonia, Spain
  1. ↵* Corresponding author. Tel: +49 89 4400 46549; Fax: +49 89 4400 46546; E‐mail: msuarez{at}barcelonabeta.org
    Corresponding author. Tel: +49 89 4400 46549; Fax: +49 89 4400 46546; E‐mail: christian.haass{at}mail03.med.uni-muenchen.de
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Article Information

vol. 10 no. 12
DOI 
https://doi.org/10.15252/emmm.201809712
PubMed 
30482868
Print ISSN 
1757-4676
Online ISSN 
1757-4684
History 
  • Published online November 27, 2018.
  • Published in print December 1, 2018.
Review Process File

Author Information

  1. Marc Suárez‐Calvet (msuarez{at}barcelonabeta.org)*,1,2,21,
  2. Anja Capell1,
  3. Miguel Ángel Araque Caballero3,
  4. Estrella Morenas‐Rodríguez1,4,
  5. Katrin Fellerer1,
  6. Nicolai Franzmeier3,
  7. Gernot Kleinberger1,5,
  8. Erden Eren1,6,7,
  9. Yuetiva Deming8,
  10. Laura Piccio9,10,
  11. Celeste M Karch8,10,11,
  12. Carlos Cruchaga8,10,11,
  13. Katrina Paumier9,10,11,
  14. Randall J Bateman9,10,11,
  15. Anne M Fagan9,10,11,
  16. John C Morris9,10,11,
  17. Johannes Levin2,12,
  18. Adrian Danek12,
  19. Mathias Jucker13,14,
  20. Colin L Masters15,
  21. Martin N Rossor16,
  22. John M Ringman17,
  23. Leslie M Shaw18,19,
  24. John Q Trojanowski18,19,
  25. Michael Weiner20,
  26. Michael Ewers3,
  27. Christian Haass (christian.haass{at}mail03.med.uni-muenchen.de)*,1,2,5,
  28. the Dominantly Inherited Alzheimer Network†,
  29. the Alzheimer's Disease Neuroimaging Initiative‡
  1. 1Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig‐Maximilians‐Universität München, Munich, Germany
  2. 2German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany
  3. 3Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig‐Maximilians‐Universität München, Munich, Germany
  4. 4Department of Neurology, Institut d'Investigacions Biomèdiques, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain
  5. 5Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
  6. 6Izmir International Biomedicine and Genome Institute Dokuz, Eylul University, Izmir, Turkey
  7. 7Department of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey
  8. 8Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
  9. 9Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
  10. 10Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO, USA
  11. 11Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, MO, USA
  12. 12Department of Neurology, Ludwig‐Maximilians‐Universität München, Munich, Germany
  13. 13German Center for Neurodegenerative Diseases (DZNE) Tübingen, Tübingen, Germany
  14. 14Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
  15. 15The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Vic., Australia
  16. 16Dementia Research Centre, UCL Institute of Neurology, London, UK
  17. 17Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
  18. 18Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  19. 19Center for Neurodegenerative Disease Research, Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  20. 20University of California at San Francisco, San Francisco, CA, USA
  21. 21Present Address: Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Catalonia, Spain
  1. ↵* Corresponding author. Tel: +49 89 4400 46549; Fax: +49 89 4400 46546; E‐mail: msuarez{at}barcelonabeta.org
    Corresponding author. Tel: +49 89 4400 46549; Fax: +49 89 4400 46546; E‐mail: christian.haass{at}mail03.med.uni-muenchen.de
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Volume 10, Issue 12
01 December 2018
EMBO Molecular Medicine: 10 (12)
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