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Pharmacology & Drug Discovery

  • Open Access
    MG132‐induced progerin clearance is mediated by autophagy activation and splicing regulation
    MG132‐induced progerin clearance is mediated by autophagy activation and splicing regulation
    Karim Harhouri, Claire Navarro, Danielle Depetris, Marie‐Geneviève Mattei, Xavier Nissan, Pierre Cau, Annachiara De Sandre‐Giovannoli, Nicolas Lévy
    Published online 03.07.2017
    • Genetics, Gene Therapy & Genetic Disease
    • Neuroscience
    • Pharmacology & Drug Discovery
  • Open Access
    Synergistic antibacterial effect of silver and ebselen against multidrug‐resistant Gram‐negative bacterial infections
    Synergistic antibacterial effect of silver and ebselen against multidrug‐resistant Gram‐negative bacterial infections
    Lili Zou, Jun Lu, Jun Wang, Xiaoyuan Ren, Lanlan Zhang, Yu Gao, Martin E Rottenberg, Arne Holmgren
    Published online 12.06.2017
    • Microbiology, Virology & Host Pathogen Interaction
    • Pharmacology & Drug Discovery
  • Open Access
    CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib
    CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib
    Eric Raspé, Katia Coulonval, Jaime M Pita, Sabine Paternot, Françoise Rothé, Laure Twyffels, Sylvain Brohée, Ligia Craciun, Denis Larsimont, Véronique Kruys, Flavienne Sandras, Isabelle Salmon, Steven Van Laere, Martine Piccart, Michail Ignatiadis, Christos Sotiriou, Pierre P Roger
    Published online 31.05.2017
    • Cancer
    • Chromatin, Epigenetics, Genomics & Functional Genomics
    • Pharmacology & Drug Discovery
  • Open Access
    γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct
    γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct
    Yong Ran, Fokhrul Hossain, Antonio Pannuti, Christian B Lessard, Gabriela Z Ladd, Joo In Jung, Lisa M Minter, Barbara A Osborne, Lucio Miele, Todd E Golde
    Published online 24.05.2017
    • Cancer
    • Neuroscience
    • Pharmacology & Drug Discovery
  • Open Access
    A clinical and mechanistic study of topical borneol‐induced analgesia
    A clinical and mechanistic study of topical borneol‐induced analgesia
    Shu Wang, Dan Zhang, Jinsheng Hu, Qi Jia, Wei Xu, Deyuan Su, Hualing Song, Zhichun Xu, Jianmin Cui, Ming Zhou, Jian Yang, Jianru Xiao
    Published online 10.04.2017
    • Neuroscience
    • Pharmacology & Drug Discovery
  • Open Access
    Ferrochelatase is a therapeutic target for ocular neovascularization
    Ferrochelatase is a therapeutic target for ocular neovascularization
    Halesha D Basavarajappa, Rania S Sulaiman, Xiaoping Qi, Trupti Shetty, Sardar Sheik Pran Babu, Kamakshi L Sishtla, Bit Lee, Judith Quigley, Sameerah Alkhairy, Christian M Briggs, Kamna Gupta, Buyun Tang, Mehdi Shadmand, Maria B Grant, Michael E Boulton, Seung‐Yong Seo, Timothy W Corson
    Published online 04.04.2017
    • Neuroscience
    • Pharmacology & Drug Discovery
    • Vascular Biology & Angiogenesis
  • Open Access
    An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice
    An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice
    Yu‐Sung Cheng, Zih‐ten Chen, Tai‐Yan Liao, Chen Lin, Howard C‐H Shen, Ya‐Han Wang, Chi‐Wei Chang, Ren‐Shyan Liu, Rita P‐Y Chen, Pang‐hsien Tu
    Published online 29.03.2017
    • Neuroscience
    • Pharmacology & Drug Discovery
  • Open Access
    Delivery is key: lessons learnt from developing splice‐switching antisense therapies
    Delivery is key: lessons learnt from developing splice‐switching antisense therapies
    Caroline Godfrey, Lourdes R Desviat, Bård Smedsrød, France Piétri‐Rouxel, Michela A Denti, Petra Disterer, Stéphanie Lorain, Gisela Nogales‐Gadea, Valentina Sardone, Rayan Anwar, Samir EL Andaloussi, Taavi Lehto, Bernard Khoo, Camilla Brolin, Willeke MC van Roon‐Mom, Aurélie Goyenvalle, Annemieke Aartsma‐Rus, Virginia Arechavala‐Gomeza
    Published online 13.03.2017
    • Pharmacology & Drug Discovery
  • Open Access
    Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis
    Targeting <em>Toxoplasma gondii </em>CPSF3 as a new approach to control toxoplasmosis
    Andrés Palencia, Alexandre Bougdour, Marie‐Pierre Brenier‐Pinchart, Bastien Touquet, Rose‐Laurence Bertini, Cristina Sensi, Gabrielle Gay, Julien Vollaire, Véronique Josserand, Eric Easom, Yvonne R Freund, Hervé Pelloux, Philip J Rosenthal, Stephen Cusack, Mohamed‐Ali Hakimi
    Published online 01.02.2017
    • Microbiology, Virology & Host Pathogen Interaction
    • Pharmacology & Drug Discovery
  • Open Access
    PERK activation mitigates tau pathology in vitro and in vivo
    PERK activation mitigates tau pathology <em>in vitro</em> and <em>in vivo</em>
    Julius Bruch, Hong Xu, Thomas W Rösler, Anderson De Andrade, Peer‐Hendrik Kuhn, Stefan F Lichtenthaler, Thomas Arzberger, Konstanze F Winklhofer, Ulrich Müller, Günter U Höglinger
    Published online 01.02.2017
    • Neuroscience
    • Pharmacology & Drug Discovery

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